When mixing grapefruit and statins, there is a chance of increased side effects. Women and people over 65 are at a higher risk of developing side effects from statins. These side effects include: muscle breakdown. liver damage. digestive problems. increased blood sugar. neurological side effects.
When statin takers eat large amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects. Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses.
Safety and Considerations. What is known is that statin drug levels can increase by anywhere from 80 percent to 260 percent if the medication is taken at the same time as grapefruit. If taken 12 hours apart, that drops to between 44 percent and 66 percent. The effect remains the same whether you cook the grapefruit or drink frozen or homogenized juice.
Grapefruit juice and statins. Why? A: Certain classes of drugs — most notably statins — are metabolized (broken down) in your intestines by an enzyme called CYP3A, which normally reduces the amount of drug that enters your bloodstream. Grapefruit juice contains compounds called furanocoumarins that stop CYP3A from doing its job.
Statins and Grapefruit Juice. Thus, in the normal state, smaller amounts of the drugs get into the body than are ingested. When the action of these enzymes is blocked (as by grapefruit juice), more of the drugs get into the body, and the blood levels of these medications increase. This can lead to toxic side effects from Lipitor, such as liver or muscle damage.
Sep 10, 2018 · How Grapefruit Juice Affects Some Drugs. Some drugs, like statins used to lower cholesterol, are broken down by enzymes. Grapefruit juice can block the action of these enzymes, increasing the amount of drug in the body and may cause more side effects. Other drugs, like Allegra (fexofenadine) used to treat allergies,