Pathophysiology of type 2 diabetes. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions of beta-cell dysfunction
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Pathophysiology of type 2 DM. Insulin secretion is increased in the earlier stages of diabetes, but declines with increasing duration as a consequence of progressive beta cell failure. Other potentially important mechanisms associated with type 2 diabetes and insulin resistance include an increase in circulating glucagon,
Dec 03, 2009 · Pathology of type 2 diabetes. In type 2 diabetes, the body either produces inadequate amounts of insulin to meet the demands of the body or insulin resistance has developed. Insulin resistance refers to when cells of the body such as the muscle, liver and fat cells fail to respond to insulin, even when levels are high.
Other type 2 diabetes risk factors include the following: High blood pressure. High blood triglyceride (fat) levels. Gestational diabetes or giving birth to a baby weighing more than 9 pounds. High-fat and carbohydrate diet. High alcohol intake. Sedentary lifestyle. Obesity or being overweight.
Although the pathophysiology of the disease differs between the types of diabetes, most of the complications, including microvascular, macrovascular, and neuropathic, are similar regardless of the type of diabetes. Hyperglycemia appears to be the determinant of …
Hannele Yki-Järvinen. The insulin resistance preceding type 2 diabetes is commonly referred to as the metabolic syndrome. The latter condition consists of a cluster of risk factors, which are thought to be either causes or consequences of insulin resistance. The development of type 2 diabetes, overt hyperglycaemia,
Diabetes Mellitus Type 2: Pathophysiology Type 2 diabetes mellitus is often associated with certain genetic predispositions, environmental factors, lifestyle choices, and the dynamic interactions between all of these different aspects.
Insulin resistance. Insulin resistance is a condition in which insulin in the body does not exert sufﬁcient action propor- tional to its blood concentration. The impairment of insulin action in major target organs such as liver and muscles is a common pathophysiologi- cal feature of type 2 diabetes.